Mesen 2 emulator

I was wondering if there was a way to use the Messen 2 emulator on a raspberry pi for very specific graphical updates like Metroid HD Also which raspberry pi would be able to run it if any

URL?

https://www.mesen.ca/

As I can see, people have installed .NET 6 Runtime and SDL2 on Raspberry Pi and that is the requirement for Messen2, So I would say yes it is possible.